PH-RESPONSIVE TARGETED NANOPARTICLES RELEASE ERK-INHIBITOR IN THE HYPOXIC ZONE AND SENSITIZE FREE GEMCITABINE IN MUTANT K-RAS-ADDICTED PANCREATIC CANCER CELLS AND MOUSE MODEL.

Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing.Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the first-line chemotherapeutic drug in the clinic for PDAC treatment.The therapeutic limitations of GEM are primaril

The effect of light on human physiology as well as its non-image forming effects have been known for several years.An important milestone in understanding the non-visual effects of light was the discovery of a new type of photoreceptor namely the intrinsically photosensitive retinal ganglion cells, or ipRGCs which play a vital role in the human cir

Traditional vegetable varieties constitute an important reservoir of biodiversity, so recovering, cultivating, and correctly classifying these landraces is part of key global heritage for the future of food security.In this study, 17 traditional pepper varieties from the Valencian Community (Spain) were characterized using 14 lorenametaute.com quan

The highly contagious nature of SARS-CoV-2 (COVID-19) virus has created a havoc effect all over the world in a very short period.The most effective method for precaution of this virus as suggested by WHO is use of PPEs (triple layered face mask, body suits) and social distancing.However, the frontline doctors and medical staff have high risk of exp

Raw milk cheeses harbor complex microbial communities.Some of these microorganisms are technologically essential, but undesirable microorganisms can also be present.While most of the microbial dynamics and cross-talking studies involving interaction between food-derived bacteria have been carried out on agar plates in laboratory-controlled conditio